|
KMID : 0338420200350061371
|
|
Korean Journal of Internal Medicine
2020 Volume.35 No. 6 p.1371 ~ p.1384
|
|
|
J-curve relationship between corrected QT interval and mortality in acute heart failure patients
|
|
Park Chan-Soon
Cho Hyun-Jai
Choi Eue-Keun
Lee Sang-Eun
Kim Min-Seok
Kim Jae-Joong
Choi Jin-Oh
Jeon Eun-Seok
Hwang Kyung-Kuk
Chae Shung-Chull
Baek Sang-Hong
Kang Seok-Min
Yoo Byung-Su
Choi Dong-Ju
Ahn Young-Keun
Kim Kye-Hoon
Cho Myeong-Chan
Oh Byung-Hee
Lee Hae-Young
|
|
|
Abstract
|
|
|
Background/Aims: This study investigated the prognostic power of corrected QT (QTc) interval in patients with acute heart failure (AHF) according to sex.
Methods: We analyzed multicenter Korean Acute Heart Failure registry with patients with AHF admitted from 2011 to 2014. Among them, we analyzed 4,990 patients who were followed up to 5 years. Regarding QTc interval based on 12 lead electrocardiogram, patients were classified into quartiles according to sex.
Results: During follow-up with median 43.7 months, 2,243 (44.9%) patients died. The relationship between corrected QT interval and all-cause mortality followed a J-curve relationship. In Kaplan-Meier analysis, both sex had lowest mortality in the second QTc quartile. There were significant prognostic differences between the second and the fourth quartiles in male (log-rank p = 0.002), but not in female (log-rank p = 0.338). After adjusting covariates, the third (hazard ratio [HR], 1.185; 95% confidence interval [CI], 1.001 to 1.404; p = 0.049) and the fourth (HR, 1.404; 95% CI, 1.091 to 1.535; p = 0.003) quartiles demonstrated increased risk of mortality compared to the second quartile in male. In female, however, there was no significant difference across quartiles. QTc interval was associated with 5-year all-cause mortality in J-shape with nadir of 440 to 450 ms in male and 470 to 480 ms in female.
Conclusions: QTc interval was an independent predictor of overall death in male, but its significance decreased in female. The relationship between QTc interval and all-cause mortality was J-shaped in both sex.
|
|
|
KEYWORD
|
|
|
Heart failure, QTc interval, Sex, Mortality, Prognosis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
    
|
|